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No major diet-related toxicities necessitating discontinuation were reported, reinforcing earlier observations that KD can be safely integrated into supportive cancer care under medical supervision

The ER also communicates with mitochondria via signaling from the unfolded protein response (UPR), which is activated by ER stress and signals through the three ER-resident stress sensors IRE1, PERK, and ATF6 (Walter and Ron, 2011)