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Glucose Tolerance in Obese Patients Two-year studies that included oral glucose tolerance tests were conducted in obese patients not previously diagnosed or treated for type 2 diabetes and whose baseline oral glucose tolerance test (OGTT) status at randomization was either normal, impaired, or diabetic

Two large Phase III trials, a Lancet HIV NAFLD study, and mechanistic transcriptomic and proteomic follow-up papers anchor the evidence base

They found that pharmacological concentrations of irisin (50100 nmol/L), but not physiological concentrations (510 nmol/L), increased the proliferation of mouse hippocampal neuronal cells via the STAT3 signaling pathway