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The expression levels of ACC and FASN, key enzymes of FA de novo synthesis pathway, are closely related to the development and progression of CCA, and it has been reported that a variety of drugs could affect the FA synthesis and metabolism to exert oncogenic effects by regulating ACC and FASN

Notably, coculture with L-Cn resulted in significantly reduced frequencies of IgG-secreting B cells and a tendency of reduced production of IgG in the supernatant by purified CD19 + B cells, relative to the control group ( Figure 3E )

Strikingly, L-Cn up-regulated the frequency of Treg cells, along with the abundance of IL-10-producing Treg cells ( Figures 4B, C )

10.1038/s41380-018-0261-8 29 DuS