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32-34 In a randomized placebo-controlled trial that included 112 symptomatic perimenopausal women, menopausal symptom scores as rated by the 44-point menopause rating scale (MRS) decreased by 14.6 points in those taking one 4 mg tablet of a standardized Siberian rhubarb daily for 12 weeks compared with a 3-point decrease in those taking placebo