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If ITCs such as sulforaphane (SFN) are widely known for their health benefits, ITC-nitriles are considered biologically inactive ( 2+ ions, temperature, and pH ( Cooking cruciferous vegetables at high temperatures such as boiling leads to a significant loss of myrosinase activity, decreasing the level of ITCs such as SFN ( 2 Metabolism of glucoraphanin in the gastrointestinal tract: role of the gut microbiota The simulation model of gastrointestinal enzymatic digestion of GRP showed that no mammalian digestive enzymes could hydrolyze GRP in vitro ( The human gastrointestinal tract (GIT) is inhabited by a significant number of diverse microorganisms that, interacting with the host, form a dynamic community defined as the gut microbiota

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Consequently, disruption of intracellular GSH homeostasis is linked to many pathologies, including cancer 4 , diabetes 5 and neurodegenerative disorders 6

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