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Description

At each time point, 3 mice were randomly selected for sampling

63,64 Ultimately, through regulation at the tissue and organ levels, these processes influence the onset and progression of diseases in the organism

S-containing metabolites, including amino acids methionine, major reductant glutathione, and specific metabolites, are synthesized from cysteine

To identify which pathway contributes most to QEC tolerance to Cys-Cys limitation, we treated QECs with specific inhibitors targeting STAT3 and NRF2 activity: AG-490 [40] and ML385 [41], respectively