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CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production

(1) Omega-3 PUFAs (EPA/DHA) as core antidepressant components Deep-sea fish (e.g., salmon, mackerel) contain 23 g/100 g of EPA and DHA, which target two key pathways of depression: Inhibiting microglial activation: by inhibiting the NF-B/MAPK p38 signaling pathway and activating the neuronal BDNF-PI3K/AKT pathway, the process achieves a balance in microglial M1/M2 polarization and provides neuroprotection against neuroinflammation (313)

4) versus those residues mediating interactions between GR and FAD within the crystallographic structure (PDB) were compared meticulously