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After the sequencing of the human genome, in the early 2000s, the Broad Institute launched in 2010 the Connectivity Map, where numerous compounds were analyzed to find out what was their influence on the expression of genes

10.1016/s0163-4453(89)80064-7 59 RimonA.RakovC.LererV.Sheffer-LeviS.OrenS

The concept of an intermediate state post-ETI is pivotal (Maher et al., 2024): patients are significantly better, but their molecular profiles do not fully normalize to that of healthy individuals