ghk-cu effect on gh igf-1 does affect or levels Correlation between GH and IGF-1 in the serum of patients with GHK-Cu (Copper Peptide) Deep Dive:

Block the pathway and hair growth stops

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When the tissue is damaged, tissue proteases break down SPARC, releasing an array of GHK and GHK-containing copper-binding peptides, which stimulate cell proliferation and new vessels growth

Using the Broad Institutes Connectivity Map, the group reported that GHK modulates the expression of a very large number of human genes, on the order of thousands, and tends to shift pathological or aged expression patterns back toward a healthier, younger profile