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When patients with JakobCreutzfeldt disease underwent PET imaging with [ 11 C] d-l-deprenyl and [ 18 F]fluorodeoxyglucose ([ 18 F]FDG), increased astrogliosis and decreased cerebral glucose metabolism were observed in the frontal, occipital and parietal cortices and cerebellum 351,352

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Reports also show that intravenous administration of PACAP-38 can elicit a migraine-like attack in patients (Schytz et al., 2009) and cause sustained meningeal vasodilation and migraine-like photophobia in mice (Markovics et al., 2012)