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Therefore, HBO's capacity to fine-tune autophagic activitypromoting its protective role in cellular clearance while curtailing its detrimental progression to programmed cell deathhighlights its potential not only in focal ischemia but also in addressing global cerebral injury following cardiac arrest and CPR, where dysregulated autophagy significantly contributes to neuronal damage

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The body mainly absorbs heme iron through endocytosis ( 2+ is released into the cytoplasm by the heme oxygenase-1 (HO-1) and stored in the active iron pool