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A multiple sclerosis suited toxic rat model, cuprizone (compared with standard, a several times higher regimen, 2.5% of diet regimen + 1 g/kg intragastrically/day) was combined with BPC 157 (in drinking water 0.16 g or 0.16 ng/ml/12 ml/day/rat + 10 g or 10 ng/kg intragastrically/day) till the sacrifice at day 4

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The second objective of the study was to clarify the general mechanism of action of these peptides by assessing their ability to affect changes in dendritic spines

Whether those studies establish a sufficient benefit-risk profile for human use through compounding pharmacies was the core scientific question, and the committee's majority answered yes over the objections of FDA scientists who answered no