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10.1371/journal.pone.0016883 79 SharpleyC

77,78 Resveratrol further regulates the MAPK/ERK1 and PI3K/Akt pathways, enhances the Nrf2/thioredoxin-1 (Trx-1) axis, inhibits HIF-1 expression, and reduces hypoxia-induced ROS production

However, it revealed no statistically significant difference in the change in UPDRS total score between the hydrogen water group and the placebo group at 72 weeks (Yoritaka et al., 2016)