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doi: 10.3390/antiox11071386 15

J Food Biochem 42:e12516

Overdose reactive intermediates/reactive metabolites are also liable to covalently bind to cellular proteins or DNA (Yan et al., 2008), and eventually initiate and trigger a series of toxic effects, including protein abnormal modification, enzyme inactivation, DNA crosslink, formation of immunogenic species, cell death, or oncogene activation, organ injury ( The present review focuses on the toxicity of natural products, analyzing the key role of metabolic activation in their toxicities

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