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Importantly, ADPR-Ub was not detectable in cells infected with the lnaB mutant but became abundant after adding recombinant LnaB (Fig

Dodge 4 and Lily Dara 2 , (1)Department of Medicine, Keck School of Medicine, University of Southern California, (2)Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, (3)Keck School of Medicine, University of Southern California, (4)USC Research Center for Liver Disease, Keck School of Medicine, University of Southern California Background: Immune checkpoint inhibitors (ICIs) are approved systemic therapy for many malignancies including HCC