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In addition to cytokines, cancer vaccines are emerging as promising immunotherapies, demonstrating a level of therapeutic efficacy that surpasses or equals that of other treatments in certain contexts, which is considered high relative to current standards of care [127]

MRX34, a miR-34a mimic, was developed to assess its safety, pharmacokinetics, and pharmacodynamics in a Phase I trial (NCT01829971)

Recently, we demonstrated that upon activation of TLR8 by specific imidazoquinolines exerting antiviral activities, including R848 and CL075, neutrophils display the capacities to produce IL-6 in biologically active amounts 8

This observation reflects the role of -SH groups in the enzyme activity of GDH