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Zinc and copper share common transport pathways, and increasing copper levels without adequate zinc can create functional deficiencies that impair immunity, wound healing, and hormone balance

Response: Although we acknowledge the applicant's concerns regarding the descriptor for C1739, we do not agree that the device category code should be withdrawn and replaced with a new code effective January 1, 2026, for the following reasons: First, per the applicant's request prior to CY 2026 rulemaking, CMS revised the descriptor for C1739 to read, effective October 1, 2025: Tissue marker, uniquely detectable and identifiable with probe/sensor, any method (implantable), with delivery system

Thus, well-designed peptides and peptide derivatives can result in improved tumor treatment

[DOI] [PubMed] [Google Scholar] 238.Wang XL, et al