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The ultimate goal is to create a more holistic research pipeline where the model can simultaneously elucidate the complex pathophysiology of liver diseases, identify and validate the mechanistic basis of phytochemical efficacy, and provide early, reliable insights into pharmacokinetics and safety

We previously published on the SM protocol ( N , N '-(Methylenedi-4,1-phenylene)bis-acetamide), FPH1 (2-(N-(5-chloro-2-methylphenyl) methylsulfonamido)-N-(2,6-difluorophenyl) acetamide), the Activin/NODAL/TGF- pathway inhibitor (A8301

This protective effect of L-glutamine appears to be mediated by the transactivation of EGF receptor leading to activation of PKC and MAPK

( b ) Beutler, E., and Duron, O., Transfusion , 5 , 17 (1965)