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7d), confirming that the need to increase mitochondrial mass in 5FU-treated cells is driven by a dependence on increased mitochondrial activity, and metformin can block this mitochondrial adaptation to prevent drug tolerance in tumours

Your skin is your bodys largest organ, a protective shield that tells a story of where youve been and, to some extent, who you are

Validation MR analysis To verify the reliability of our experimental results, we introduced external validation exposures and outcomes

For example, ECM proteins crucial for cartilage structure and maintenance, such as ACAN, DCN, HSPG2, BGN, and FBLN1 were downregulated in the conditioned medium of H 2 O 2 -treated cells compared to those in control cells