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Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo

Babula JJ, Bui D, Stevenson HL, et al

Since subcutaneous adipocytes typically display lower densities of GH receptors than visceral adipocytes, they may not respond as well to GH-induced or Frag 176-191-mediated lipolysis, possibly resulting in differential regional adipose mobilization

Patients with significantly suppressed baseline IGF-1 (typically below 150 ng/mL in adults over 40) tend to see the most pronounced early changes because the distance from baseline to optimized is greatest