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CB can accelerate lung function decline, increase COPD exacerbation frequency, and reduce HRQoL 43

The early rapid phase of endothelial cell activation, termed type 1 activation, involves the remodeling of endothelial cell-cell junctions enhancing monolayer permeability (Figure 2(a)) and the export of Weibel-Palade bodies presenting P-Selectin and vWF at the endothelial cell surface [52]