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Figure 2 2.1.1 Effects on innate immune system Neutrophils are the most abundant leukocytes population in peripheral blood, and they exert their activity early during inflammation, releasing cytokines, proteases, producing reactive oxygen species (ROS), and creating neutrophils extracellular traps (NETs) (33) Neutrophils represent the main targets of A1AT action: being an anti-protease, its primary effect is to inhibit serine proteases deriving from degranulating neutrophils including NE, cathepsin G and PR3 (34)

The prolonged winter season on the Qinghai-Tibet Plateau is marked by pasture senescence, during which crude protein content can decline to as low as 36%, far below the maintenance requirements of yaks (9), resulting in body weight losses of 2030% (10)

54 When a patient develops ARDS, along with regular antiviral therapy, 150 mg/kg at the first day, followed by a dose of 100 mg/kg/day for at least 3 days, should be administrated to avoid irreversibly fatal multiple organ failure (MOF)

The neuropsychiatric symptoms observed in penicillin G cohort included dysphoria ( n = 10), disorganized speech ( n = 8), abnormal behaviour ( n = 6), consciousness disorder ( n = 6), slow reaction ( n = 4), hallucination ( n = 4), seizures ( n = 3), memory decline ( n = 3), emesis ( n = 2), urinary incontinence ( n = 2), myoclonus ( n = 1), encopresis ( n = 1), aphasia ( n = 1) (Fig