glutathione overview The Role of the System in Stress Adaptation, Morphogenesis and Virulence of Pathogenic Fungi What Is Glutathione? A Summary

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Cell Mol Life Sci 76(10):18771887

Abbreviations CCA: Cholangiocarcinoma SLC: Solute carrier FGFR: Fibroblast growth factor receptor IDH1: Isocitrate dehydrogenase 1 -KG: Alpha-ketoglutarate ROS: Reactive oxygen species ACSL4: Acyl-CoA synthetase long chain family member 4 LPCAT3: Lysophosphatidylcholine acyltransferase 3 GPX4: Glutathione hydroperoxidase 4 OGC: Oxoglutarate carrier PUFAs: Polyunsaturated fatty acids HR: Hazard ratio TCGA: The Cancer Genome Atlas GEO: Gene expression omnibus IHC: Immunohistochemistry m: Mitochondria membrane potential TMRE: Tetramethylrhodamine ethyl ester perchlorate ETC: Electron transport chain PEBP1: Phosphatidylethanolamine binding protein 1 Fer-1: Ferrostatin-1 IPA: Ingenuity pathway analysis NRF2: Nuclear factor erythroid 2-related factor 2 CUL3: Cullin3 CRLs: Cullin-RING E3 ligase complex HIF-1: Hypoxia inducible factor 1 subunit alpha GSH: Glutathione ALOX: Arachidonate lipoxygenase ICD: Immunogenic cell death DAMPs: Damage-associated molecular patterns HMGB1: High-mobility group box 1 ATP: Adenosine 5-triphosphate CRT: Calreticulin References Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, et al

However, these advancements are accompanied by growing environmental and public health concerns stemming from the release of active pharmaceutical ingredients (APIs) into ecosystems [39, 136]