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As Medical News Todays medically reviewed assessment states: Researchers have not confirmed the effectiveness of lipotropic injections and research has not confirmed that taking doses of vitamin B-12 or methionine above the recommended amount helps a person lose weight. Healthline similarly notes that limited research exists on their efficacy. This evidence gap does not mean the injections have no biological basis

Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children

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The therapeutic window appears narrow