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An example is mature BDNF, which has been targeted to secretory vesicles within RGCs by adeno-associated virus gene therapy, increasing BDNF production and long-term BDNF receptor expression in a mouse model of optic nerve damage and in a rat model of chronic IOP, which provides neuroprotection against RGCs (197)

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Generally, the entire process from linker design and synthesis to provision of preliminary samples takes about 4 to 8 weeks