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Tracking your IGF-1 levels, growth hormone levels, and other key biomarkers can help you avoid potential issues such as receptor desensitization and insulin resistance, which may arise from improper use or excessive dosing of IGF-1 LR3

The concern discussed in the literature is narrower and more specific: sustained IGF-I elevation is theoretically undesirable in the presence of an undetected existing malignancy, because IGF-I is a growth factor for tissue that is already there