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10.1016/j.etap.2023.104218 26 ChaudhryA.SamsteinR

In the case of early IVD degeneration with minor clinical signs, there is the ethical issue of whether the risks of an intradiscal injection are not higher than the benefit that may be expected from the novel regenerative treatment [89]

On the contrary, the protein showed a stable fluctuation range of 0.801.50

Why the elevation of HIF-1 in the intestinal tissues of UC patients did not play a protective role and alleviate colitis, we speculate that the pathologically elevated level of HIF-1 may not be sufficient to play a protective effect by inducing the expression of relevant protective genes, therefore, intervention with PHDs inhibitor (DMOG) in this study resulted in increasingly stable expression levels of HIF-1 in the intestines of colitis mice, contributing to the protection of intestinal barrier function by inducing the expression of protective genes