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By interfering with NF-kB nuclear translocation, KPV reduces the production of key pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6, all of which are elevated in active lupus

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In contrast, extending the BSO treatment to 24 h after drug exposure potentiated the cytotoxicity of cisplatin, CHIP and tetraplatin.(ABSTRACT TRUNCATED AT 400 WORDS) This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 24 print issues and online access $259.00 per year only $10.79 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

Future research should focus on identifying stage-specific ferroptosis regulators, optimizing drug delivery to the CNS, and validating safety and efficacy in large-scale clinical trials