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Reasonable people can disagree about where the balance should be

For GHK-Cu, whether the endpoint is skin, joint, or vascular tissue repair, localized depot release via SubQ outperforms IM systemic distribution

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[6] [42] [43] For single doses of lipophilic, multi-compartment drugs, clinical duration after onset is often driven by the distribution () phase, because by the time distribution equilibrium is reached plasma levels are frequently below any minimal effective concentration, so the terminal phase has little bearing on observable effects