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In most diseases, ROS appear to have a direct connection with inflammaging and cell senescence, and oxidative stress and inflammaging increase the aging-related phenotype, and induce and aggravate the inflammatory response, creating a chronic state of systemic inflammation (290297)

These support the liver's phase 2 detoxification pathways

Neurochem Res 36:22442249 Kabuto H et al (2005) Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum

Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling