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Overall, parent genes of multiple cognition-associated proteoforms within signalling and scaffolding functional modules are enriched in cell-types with recurrent links to cognitive resilience and frailtySST INs and IT neurons 14,20,21,58,84

[Updated 2023 Jul 24]

Advances in gene therapy and small molecules able to upregulate EAAT2 expression are under investigation as potential intervention 35 that could mitigate oxidative stress and excitotoxicity, reducing neuronal damage

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