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Indeed, PM2.5 has been demonstrated to inflict damage upon a multitude of bodily systems through the induction of oxidative stress, inflammation, and regulated cell death (including apoptosis, necroptosis, and pyroptosis) [65, 66]

Human aldose reductase: Rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme

Eisa EA, Honfi P, Tilly-Mndy A, Mirmazloum I

PLoS One 15, e0240789 (2020), Abstract Full Text 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates: K