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Our S-Acetyl L-Glutathione Story We spotted a fundamental challenge with glutathione supplementation: despite being one of the body's most critical protective compounds, standard reduced glutathione has limited bioavailability and requires high doses (500-1,000mg) taken over weeks to see meaningful increases in tissue levels

Mol Biol Rep 38:11151119

Conclusions Here, we report a case of a neonate with severe GSSD carrying compound heterozygous variants in GSS , expanding the varietal spectrum