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(18) Contraindications for Estrogen Therapy: Previous history of VTE (Venous thromboembolism) History of estrogen-sensitive neoplasm Advanced stages of chronic liver disease Hypertriglyceridemia (relative contraindication) (19) Ask yourself

For example, the widely used chemotherapeutic drugs doxorubicin (DOX), cisplatin (CIS), Fluorouracil (5-FU), methotrexate (MTX) and tamoxifen (TAM) have high antitumor efficacy, meanwhile with serious damage to multiple organs (e.g., cardiomyopathy, acute renal failure, acute toxic leukoencephalopathy, hepatic steatosis and testicular toxicity) (154158)

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University of Montreal and McGill University Montreal, QC, Canada Council on Hypertension (formerly Council on High Blood Pressure Research) For 40 years, Dr