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(2018) 178:K19

Nat Commun 3 , 718 (2012)

In an LPS-induced mouse model of PD, administration of Rg1 was shown to reduce the activation of microglia and astrocytes, decrease levels of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, elevate anti-inflammatory factors, and mitigate the loss of nigral dopaminergic neurons [187, 188]

Possible (usually mild) side effects may include: Temporary discomfort or bruising at the injection site Mild headache or nausea in some individuals Rare irritation of the vein (phlebitis) Very rare allergic reactions (screened during pre-treatment assessment) Guided by international clinical standards (Cleveland Clinic, NHS protocols) Serious complications are uncommon when IV infusion therapy is delivered in a controlled clinical setting with appropriate patient selection and monitoring