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Therefore, there is a need for new drug candidates, especially innovative candidates with new targets

Regarding adults, HGH has other described functions, including increasing lipolysis and lipid oxidation, which leads to mobilization of stored triglycerides, stimulation of protein synthesis that includes skeletal muscle anabolism, antagonism of insulin action that leads to glucose intolerance, and decrease of phosphate, water, and sodium renal excretion ( HGH exerts its effects through the JAK-STAT signaling pathway, influencing growth and metabolism across various tissues and organs, particularly cartilage and bone development

Findings: Studies showed increased collagen production and improved tissue repair mechanisms in experimental models

The increasing Fe2+ concentration further disrupts Ca2+ flow, leading to reduced contractile activity (153,154)