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PET scans have revealed a significant reduction in dopamine levels in the striatum, including the caudate nucleus and putamen, which disrupted dopamine signaling

Polypharmacologic reprogramming of tumor-associated macrophages toward an inflammatory phenotype

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Furthermore, GLP-1RA-induced weight loss alters adipokine profiles, lowering leptin and increasing adiponectin, which may reduce Th1/Th17 polarization and improve insulin sensitivity, thereby indirectly influencing autoimmune disease activity [28]