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Washout periods: for crossover designs, a 7-14 day washout should be adequate given both short serum half-life and the typical decay timeline of tissue-level effects post-dosing

We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion

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Mazzuca M, Maubert MA, Damaj L, Clot F, Cadoudal M, Dubourg C, et al