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Luo X, Gong HB, Li ZC, Li DD, Li ZX, Sun J et al (2024) Phospholipid peroxidation in macrophage confers tumor resistance by suppressing phagocytic capability towards ferroptotic cells

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AQ amodiaquine AQ-SG 5-glutathion- S -yl-amodiaquine AQ-QI amodiaquine-quinoneimine BSO L -buthionine-sulfoximine CDNB 1-chloro-2, 4-dinitrobenzene CYP cytochromes P450 DEAQ N -desethylamodiaquine DEAQ-SG 5-glutathion- S -yl- N -desethylamodiaquine DEAQ-QI N -desethylamodiaquine-quinoneimine DMEM Dulbeccos modified Eagle medium DMF N,N -dimethylformamide ER endoplasmic reticulum FBS fetal bovine serum GSH glutathione GSSG glutathione disulfide GST glutathione S -transferase H 2 O 2 hydrogen peroxide HClO 4 perchloric acid HRP horseradish peroxidase NQO1 NAD(P)H:quinone oxidoreductase 1 NAPQI N -acetyl- p -benzoquinonimine PBS phosphate-buffered saline QI quinoneimine

Glutathione is the bodys master antioxidant a tripeptide synthesized in every cell that neutralizes reactive oxygen species, drives Phase II hepatic detoxification, supports immune function, and protects mitochondrial integrity

Contact your provider if bruising spreads beyond the immediate injection area, if you develop warmth, increasing redness, or pus at the site (signs of infection), or if you experience severe pain, swelling that restricts movement, or symptoms of an allergic reaction (hives, difficulty breathing, swelling of face or throat)