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3.2.1 Nano drug delivery system Studies on nanomaterial drug delivery systems have shown that therapeutic agents coated with nanomaterials can change the overall drug particle size and maintain stable circulation in the blood to avoid their rapid removal from circulation by the reticuloendothelial system (RES) and excretion through glomerular filtration

In vitro experiments revealed that high glucose-conditioned hippocampal neurons inhibited the differentiation of NSCs, and the application of an anti-RGMa antibody restored it

These included reductions in functional and cardiovascular age, greater exercise tolerance, and notably lower mortality: treated individuals had 28% fewer deaths overall, about half the cardiovascular mortality, and reduced incidence of heart failure & respiratory disease compared to controls