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The nanoparticles, coloaded with doxorubicin and hydroxychloroquine (HCQ), released their cargo within acidic lysosomes, where doxorubicin exerted cytotoxic effects, and HCQ blocked protective autophagy and reprogrammed M2-like TAMs to the M1 phenotype by activating NF-B and increasing TNF- and IL-6 secretion