foxo4-dri peptide senolytic 2023 2024 study Frontiers Computational design of peptide targeting

Computational design of peptide targeting FOXO4. a, Domains of FOXO4 Download Scientific Diagram FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology FOXO4 DRI improves spermatogenesis in aged mice through reducing senescence associated secretory phenotype secretion from Leydig cells ScienceDirect The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications

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