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AMPK activation = increased glucose uptake and fat oxidation Downregulates anabolic processes that consume ATP Promotes mitochondrial biogenesis and cellular resilience MOTSc functions as a mitochondrial-encoded hormone that enhances metabolic flexibility and insulin sensitivity. Lee et al., Cell Metabolism Natural Expression and Peptide Supplementation Your body naturally produces MOTSc, particularly during fasting or exercise

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Passive Avoidance Passive avoidance apparatus, (UgoBasile, Italy) composed of light and dark compartments with equal sizes separated by an automatic sliding door, was used

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gtzsche PC, Ioannidis JP, et al