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According to previous studies, MSCs exert immunomodulatory effects on pro-inflammatory (M1)/pro-regenerative (M2) macrophages via the secretion of various soluble bioactive factors, such as IL-10, TGF-, prostaglandin (PGE2), tumor-necrosis-factor-inducible gene 6 protein (TSG-6), and monocyte chemoattractant protein-1 (MCP-1).[14]

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