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doi: 10.3389/fimmu.2025.1593263 Received 13 March 2025 Accepted 26 June 2025 Published 21 July 2025 Volume 16 - 2025 Edited by Rajko Reljic, University of London, United Kingdom Reviewed by Angelo Izzo, Royal Prince Alfred Hospital, Australia Angel Alejandro Oate, University of Concepcion, Chile Premanshu Dandapat, Indian Council of Agricultural Research (ICAR), India Updates Copyright 2025 Almujri, Stylianou, Nicastri, Satti, Korompis, Li, De Voss, Polo Peralta Alvarez, Tanner, Bettencourt, Ternette and McShane

Factors contained in exosomes have the capacity to direct organ tropism, modulate immune evasion, support mesenchymal-to-epithelial transition (MET), and they are predictive of metastasis and patient outcome