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In the early stages of Alzheimers we see a reduction in the metabolic activity of neurons and glucose uptake, Muoz continues, and this fits perfectly with the fact that these oligomers do not kill neurons immediately, because neuronal death occurs when severe symptoms are observed (or vice versa), such as major memory losses and lack of spatial awareness

Copper deficiency may result in decreased expression of adhesion molecules, such as ICAM-1 and VCAM-1, which facilitate leukocyte adhesion onto activated endothelial cells [78]

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