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Recent clinical trials support the beneficial effects of NO pretreatment in ischemiareperfusion-mediated tissue injury ( 2 - forming RNS, peroxynitrite (ONOO ) and nitrogen dioxide (NO 2 )

In accordance with such a variety of functions, isoforms of this heterogeneous protein family are found in many prokaryotes as well as in the cytosol, nucleus, mitochondria, chloroplasts and/or secretory pathway of eukaryotes 1,2,3,4,5,6,7,8