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Probiotics are now chiefly marketed in two forms: as conventional foods and as dietary supplements, the latter of which falls under the regulatory authority of the Food and Drug Administration (FDA) (99, 101)

The KATE2 phase II study compared T-DM1 with and without atezolizumab in a/m disease after the first line with no significant improvement in PFS in the ITT analysis, though patients in the treatment arm experienced increased toxicity requiring early unblinding of the treatment arms

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