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in contrast, the activation of the NF-B pathway can upregulate the expression of the iron-sequestering cytokine LCN2, reducing the sensitivity of glioma cells to ferroptosis inducers (Lan et al., 2023)

Comment: A commenter requested that CMS confirm that the proposed amendments to 401.305 would not impose any 6-month or other regulatory clock on the first investigation that results in the identification of an initial overpayment