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50,53 The evaluation of both the dissociation and association rate constants allowed us to determine the dissociation constants (K D ) for each complex (Table 1)

Cultures were imaged with the Opera Phenix Plus High-Content Screening System (PerkinElmer) for 4 h at 37 C with 5% CO 2

Collectively, the purpose of this work was to address this knowledge gap via a clinical pharmacokinetic kratom-drug interaction study involving healthy adult participants